"The right to play God - that right is now mine!"
Ten long years since The Mansion Incident. Since members of Raccoon City's Special Tactics And Rescue Service were betrayed by their commander Albert Wesker, defeated the ultimate bioweapon, the Tyrant, and escaped Umbrella's secret underground labs. Months after, Raccoon City itself was obliterated by nuclear strike, following a T-Virus outbreak which turned the city's inhabitants into zombies - and other, far more terrible creatures.
Chris Redfield, former S.T.A.R.S. member and Spencer Mansion survivor, is now an agent of the Bioterrorism Security Asssessment Alliance - an organisation set up to deal with the fallout following the collapse of Umbrella Corp. Umbrella's Bio-Organic Weapons research has reached terrorist organisations, and fear is high that another Raccoon City cataclysm could occur.
Teaming up with fellow BSAA operative Sheva Alomar, Chris heads to Africa's Kijuju region, to a rendezvous with a contact named Irving - only for the pair to find themselves confronted with an army of infected villagers. Beating back the bloodthirsty hordes, Chris and Sheva follow Irving's trail - and unwittingly stumble into a much larger conspiracy. Still haunted by the loss of his former partner, Jill, Chris will face a virus-powered Wesker, seek the truth behind Jill's apparent murder, and ultimately uncover the origins of Umbrella's entire research; the Progenitor Virus.