Infinity Ward's Xbox 360, PlayStation 3 and PC action game sauntered off with the publically-voted prize at the 2010 GAME British Academy Video Games Awards, beating competition from the likes of Batman: Arkham Asylum and Uncharted 2: Among Thieves.
The game has proven to be an unprecedented sales phenomenon since it came out last November, ranking as the biggest seller of 2009 and shattering entertainment industry records with its gargantuan launch success.
However, it was not the only game to win big at the prestigious event, which was hosted by top Irish comic Dara O'Briain.
Rocksteady Studios' acclaimed Batman: Arkham Asylum won two of the night's most coveted prizes after taking home the gongs for best game and best gameplay.
Treasure hunter Nathan Drake also made sure to grab his share of the spoils, with his latest adventure Uncharted 2 winning four awards, more than any other game.