Activision's first-person shooter smashed sales records when it was released in November, with its first-week takings totalling $550 million (£342 million).
The appetite of British gamers for the Xbox 360, PlayStation 3 and PC title remains undiminished, as Call of Duty: Modern Warfare 2 is still at the top of the all formats chart.
It is the seventh consecutive week it has been in the number one spot.
Football title FIFA 10 remains in second place, continuing to record strong sales three months after its release.
Assassin's Creed II fills third spot, while the rest of the top ten is dominated by Wii titles.
Wii Sports Resort, Mario & Sonic at the Olympic Winter Games, Wii Fit Plus and New Super Mario Bros. Wii occupy places four to seven, with Mario Kart Wii at nine.
The only new entry in the top ten is James Cameron's Avatar: The Game at eight.