Chatting to GameTrailers, senior vice president for PlayStation brand marketing Guy Longsworth said Activision's blockbuster shooter series will hit PS Vita in autumn, promising it will be an "absolute game-changer".
Little is known about the PS Vita version of Call of Duty, with no indication yet of whether it will be a conversion of a home console title or an entirely new experience.
However, a fully-fledged Call of Duty game will likely be a massive boon for the new system, with last year's Call of Duty: Modern Warfare 3 shattering all entertainment industry records with its billion-dollar launch in November 2011.
PS Vita's library is already looking well-stocked in terms of big-name franchises, with Uncharted: Golden Abyss, FIFA Football, Ultimate Marvel vs Capcom 3 and WipEout 2048 all among the launch titles.
Meanwhile, new PS Vita entries in the Silent Hill, Bioshock, Assassin's Creed and Street Fighter franchises are all on the way soon.